期刊
APPLIED SCIENCES-BASEL
卷 2, 期 2, 页码 465-478出版社
MDPI
DOI: 10.3390/app2020465
关键词
PET; MRI; metallofullerene; iodination
类别
资金
- National Institutes of Health, National Cancer Institute [R01 CA119371]
- National Science Foundation, Nanoscale Interdisciplinary Research Team [DMR-0507083]
- Center for Innovative Technology, Commonwealth of Virginia, Virginia Commonwealth Technology Research Fund
The current report describes the development of a dual modality tomographic agent for both positron emission tomography and magnetic resonance imaging (PET/MRI). The dual-modality agent in this study was based on a I-124 (PET) radiolabeled tri-gadolinium endohedral metallofullerene Gd3N@C-80 (MRI) nanoprobe platform. The outer surface of the fullerene cage of the Gd3N@C-80 metallofullerenes was surface functionalized with carboxyl and hydroxyl groups (f-Gd3N@C-80) using previously developed procedures and subsequently iodinated with I-124 to produce I-124-f-Gd3N@C-80 nanoprobe. Orthotopic tumor-bearing rats were infused intratumorally by convection-enhanced delivery (CED) with the I-124-f-Gd3N@C-80 agent and imaged by MRI or micro PET. The anatomical positioning and distribution of the I-124-f-Gd3N@C-80 agent were comparable between the MRI and PET scans. The I-124-f-Gd3N@C-80 dual-agent distribution and infusion site within the tumor was clearly evident in both T-1- and T-2-weighted MR images. The results demonstrate the successful preparation of a dual-modality imaging agent, I-124-f-Gd3N@C-80, which could ultimately be used for simultaneous PET/MR imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据