期刊
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13756-018-0395-0
关键词
Surgical glove; Perforation; Bacterial migration; Antimicrobial efficacy; Surgical site infection; Bacterial skin flora; Antimicrobial glove; Chlorhexidine; Antiseptic
类别
资金
- Institute for Hygiene and Applied Immunology, Medical University of Vienna
Background: The risk of SSI increases in the presence of foreign materials and may be caused by organisms with low pathogenicity, such as skin flora derived from hands of surgical team members in the event of a glove breach. Previously, we were able to demonstrate that a novel antimicrobial surgical glove coated chlorhexidine-digluconate as the active ingredient on its inner surface was able to suppress surgeons' hand flora during operative procedures by a magnitude of 1.7 log(10) cfu/mL. Because of the clinical design of that study, we were not able to measure the full magnitude of the possible antibacterial suppression effect of antimicrobial gloves over a full 3 h period. Methods: The experimental procedure followed the method for assessment of the 3-h effects of a surgical hand rub's efficacy to reduce the release of hand flora as described in the European Norm EN 12791. Healthy volunteers tested either an antimicrobial surgical glove or non-antimicrobial surgical latex gloves in a standardized laboratory-based experiment over a wear time of 3 h. Results: Wearing antimicrobial surgical glove after a surgical hand rub with 60% (v/v) n-propanol resulted in the highest 3-h reduction factor of 2.67 log(10). Non-antimicrobial surgical gloves demonstrated significantly lower (p <= 0.01) 3-h reduction factors at 1.96 log(10) and 1.68 log(10), respectively. Antibacterial surgical gloves are able to maintain a sustainable bacterial reduction on finger tips in a magnitude of almost 3 log(10) (log(10) 2.67 cfu) over 3 h wear time. Conclusion: It was demonstrated that wear of an antibacterial surgical glove coated with chlorhexidine-digluconate is able to suppress resident hand flora significantly over a period of 3-h.
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