期刊
ANNUAL REVIEW OF VIROLOGY, VOL 1
卷 1, 期 -, 页码 307-331出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-031413-085500
关键词
horizontal gene transfer; CRISPR-Cas; abortive infection; toxin-antitoxin; bacteriophages; phage resistance; Argonaute
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/G000298/1, BB/H002677/1] Funding Source: Medline
- BBSRC [BB/G000298/1, BB/H002677/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G000298/1, BB/H002677/1] Funding Source: researchfish
Bacteriophages (phages) specifically infect bacteria and are the most abundant biological entities on Earth. The constant exposure to phage infection imposes a strong selective pressure on bacteria to develop viral resistance strategies that promote prokaryotic survival. Thus, this parasite-host relationship results in an evolutionary arms race of adaptation and counter-adaptation between the interacting partners. The evolutionary outcome is a spectrum of remarkable strategies used by the bacteria and phages as they attempt to coexist. These approaches include adsorption inhibition, injection blocking, abortive infection, toxin-antitoxin, and CRISPR-Cas systems. In this review, we highlight the diverse and complementary antiphage systems in bacteria, as well as the evasion mechanisms used by phages to escape these resistance strategies.
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