期刊
ANIMAL HEALTH RESEARCH REVIEWS
卷 14, 期 1, 页码 30-39出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1466252312000242
关键词
Listeria monocytogenes; pregnancy; animal model
资金
- NCRR NIH HHS [T32 RR023916] Funding Source: Medline
- NIH HHS [T32 OD010423] Funding Source: Medline
Listeria monocytogenes causes several clinical manifestations in humans and domestic animals. This bacterium is a saprophyte in soil and ensiled feeds, which are sources of infection for food producing animals (i.e. ruminants). The most common route of infection for people is via ingestion of contaminated ready-to-eat food products such as produce, soft cheeses and deli meats. In the United States, L. monocytogenes causes relatively few cases of clinical disease compared to other food-borne pathogens. However, clinical listeriosis is associated with high mortality, especially in immunocompromised patients, pregnant women, neonates, and the elderly. Listeria is an intracellular pathogen, which has been widely used in basic research to elucidate mechanisms of molecular pathogenesis and protective cell-mediated immunity. Despite the sizeable knowledge on L. monocytogenes pathogenesis, key points regarding listeriosis during pregnancy and the perinatal period remain unknown. This review summarizes listeriosis in humans and domestic animals during pregnancy, and animal models used to study the pathogenesis and immune response to L. monocytogenes infection during these periods.
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