期刊
ADVANCED SCIENCE
卷 5, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/advs.201800581
关键词
combined therapy; iridium complexes; polydopamine; thermal/photoacoustic/lifetime imaging
资金
- National Natural Science Foundation of China [21778078, 21571196, 21572282, 2187100x]
- 973 program [2014CB845604, 2015CB856301]
- Ministry of Education of China [IRT-17R111]
- Guangdong Natural Science Foundation [2015A030306023]
- Fundamental Research Funds for the Central Universities
Recently, phosphorescent iridium complexes have demonstrated great potential as anticancer and imaging agents. Dopamine is a melanin-like mimic of mussel adhesive protein that can self-polymerize to form polydopamine (PDA) nanoparticles that demonstrate favorable biocompatibility, near-infrared absorption, and photothermal effects. Herein, PDA nanoparticles are functionalized with beta-cyclodextrin (CD) substitutions, which are further assembled with adamantane-modified arginine-glycine-aspartic acid (Ad-RGD) tripeptides to target integrin-rich tumor cells. The thus formed PDA-CD-RGD nanoparticles can deliver a phosphorescent iridium(III) complexes LysoIr ([Ir(ppy)(2)((L))]PF6, ppy = 2-phenylpyridine, L = (1-(2-quinolinyl)-beta-carboline) to form a theranostic platform LysoIr@PDA-CD-RGD. It is demonstrated that LysoIr@PDA-CD-RGD can be applied for targeted combined cancer photothermal-chemotherapy and thermal/photoacoustic/two-photon phosphorescence lifetime imaging under both in vitro and in vivo conditions. This work provides a useful strategy to construct multifunctional nanocomposites for the optimization of metal-based anticancer agents for further biomedical applications.
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