期刊
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
卷 70, 期 -, 页码 358-361出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2053230X14002593
关键词
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资金
- National Health and Medical Research Council of Australia (NHMRC)
- Cancer Australia
- Australian Cancer Research Foundation
- Victorian Government Operational Infrastructure Support Scheme
- Leukaemia Foundation
Interleukin-3 (IL-3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL-3 receptor-specific alpha subunit (IL3R alpha) is overexpressed on stem cells/progenitor cells of patients with acute myeloid leukaemia, where elevated receptor expression correlates clinically with a reduced patient survival rate. The monoclonal antibody (MAb) CSL362 is a humanized MAb derived from the murine MAb 7G3, originally identified for its ability to specifically recognize the human IL-3 receptor and for blocking the signalling of IL-3 in myeloid and endothelial cells. In order to elucidate the molecular mechanism of CSL362 antagonism, a preliminary structure of human IL3R alpha in complex with the MAb CSL362 has been determined.
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