期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 12, 页码 4051-4061出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00885
关键词
peptides; self-assembly; biofilm; cell adhesion; implants
资金
- Israeli Innovation Authority
- Rosetrees Trust
- Israel National Nanotechnology (INNI) Focal Technology Area (FTA) Project
- Clore Foundation
Due to extension of life expectancy, millions of people suffer nowadays from bone and dental malfunctions that can only be treated by different types of implants. However, these implants tend to fail due to bacterial infection and lack of integration with the remaining tissue. Here, we demonstrate a new concept in which we use specifically designed peptides, in a Lego-like manner to endow multiple preprogrammed functions. We developed a bifunctional peptide-based coating that simultaneously rejects the adhesion of infecting bacteria and attracts cells that build the new connecting tissue. The peptide design contains fluorinated phenylalanine that mediates the self assembly of the peptide into a coating that resists bacterial adhesion. It also includes an Arg-Gly-Asp (RGD) motif that attracts mammalian cells. The whole compound is attached to the surface using a third unit, the amino acid 3,4-dihydroxyphenylalanine (DOPA). This novel, yet very simple approach is significantly advantageous for practical use and synthesis. More importantly, this peptide design can serve as a general platform for generating functional coatings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据