期刊
ONCOIMMUNOLOGY
卷 4, 期 3, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21624011.2014.970918
关键词
cancer immunotherapy; immune stimulation; autoimmune pathology; 4-1BB; tumor stroma; VEGF; tumor targeting
Systemic administration of immune modulatory antibodies to cancer patients is associated with autoimmune pathologies. We have developed a clinically feasible and broadly applicable approach to limit immune stimulation to disseminated tumor lesions using a bi-specific agonistic 4-1BB oligonucleotide aptamer targeted to a broadly expressed stromal product (e.g., VEGF or osteopontin). The stroma-targeted aptamer conjugates engendered potent antitumor immunity against unrelated tumors and exhibited a superior therapeutic index compared to non-targeted agonistic 4-1BB antibody.
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