期刊
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
卷 7, 期 -, 页码 219-225出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/TCRM.S18297
关键词
chlorhexidine; poly (methyl methacrylate); eluates; antifungal drug; denture stomatitis; Candida albicans
Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans. Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a well technique on Saboraud culture medium inoculated with a resistant strain of C. albicans. Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans. Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.
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