期刊
ONCOIMMUNOLOGY
卷 4, 期 9, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1038689
关键词
oncolytic virus; vaccinia virus; pancreatic cancer; immunotherapy; IL-10
资金
- Cancer Research UK [12008] Funding Source: researchfish
- MRC [MR/M015696/1] Funding Source: UKRI
- Cancer Research UK [12008] Funding Source: Medline
- Medical Research Council [MR/M015696/1] Funding Source: Medline
Although the profile of safety of tumor-targeted oncolytic virus (TOV) is encouraging, the antitumor efficacy of TOV alone is disappointing. Interleukin-10 (IL-10) plays an important role in carcinogenesis and anti-virus immunity. Here we report that tumor-targeted oncolytic vaccinia virus (VV) armed with IL10 shows promising potential for treatment of pancreatic cancer (PaCa).
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