期刊
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
卷 4, 期 3, 页码 127-137出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1758834012439338
关键词
breast cancer; chemotherapy; endocrine therapy; estrogen receptor; human epidermal growth factor receptor 2; prognosis
类别
Use of chemotherapy for patients with estrogen receptor (ER)-positive breast cancer has been a conflicting issue. Recent studies have identified predictive markers allowing identification of poor-prognosis ER-positive breast cancers in need of more aggressive therapy. In general, tumours belonging to the so-called luminal B class, tumours expressing a high Ki67, human epidermal growth factor receptor 2 (HER-2) overexpression or a high score on the Oncotype DX gene expression profile reveal a poor prognosis compared with ER-rich tumours of the luminal A class. In contrast, recent studies have shown these tumours, contrasting tumours of the luminal A class, to benefit from more aggressive anthracycline-containing chemotherapy including a taxane. In the case of metastatic disease, patients with HER-2-positive, ER-positive tumours may benefit from having endocrine therapy and an anti-HER-2 agent administered in combination.
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