期刊
STEM CELL REPORTS
卷 2, 期 6, 页码 780-793出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2014.05.005
关键词
-
资金
- Komen for the Cure grant [BCTR0707974]
- Avon Foundation
- Breakthrough Breast Cancer
- Marion Burn Foundation
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据