期刊
STEM CELL REPORTS
卷 1, 期 4, 页码 283-292出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2013.08.007
关键词
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资金
- Highway Project for Realization of Regenerative Medicine (Ministry of Education, Culture, Sports, Science and Technology)
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program, Japan Society for the Promotion of Science)
- Shimizu Foundation for Immunology and Neuroscience Grant
- Grants-in-Aid for Scientific Research [24790276, 24592124] Funding Source: KAKEN
Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using cells derived from apatient's own cells. However, the immunogenicity of iPSCs or their derivatives has been a matter of controversy, and up to now there has been no direct comparison of autologous and allogeneic transplantation in the brains of humans or nonhuman primates. Here, using nonhuman primates, we found that the autologous transplantation of iPSC-derived neurons elicited only a minimal immune response in the brain. In contrast, the allografts caused an acquired immune response with the activation of microglia (IBA-1(+)/MHC class II+) and the infiltration of leukocytes (CD45(+)/CD3(+)). Consequently, a higher number of dopaminergic neurons survived in the autografts. Our results suggest that the autologous transplantation of iPSC-derived neural cells is advantageous for minimizing the immune response in the brain compared with allogeneic grafts.
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