期刊
ONCOIMMUNOLOGY
卷 4, 期 12, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1048956
关键词
CAR T cells; glioblastoma; EGFRvIII; adoptive cell therapy
Chimeric antigen receptor (CAR)-modified T cells directed against CD19 can mediate long-term durable remissions in B cell malignancies, but bringing a new target antigen to the clinic requires extensive modeling to avoid on-target and off-target toxicity. We recently described a systematic approach to test a new CAR directed against EGFR variant III.
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