期刊
NATURE PLANTS
卷 1, 期 10, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NPLANTS.2015.145
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资金
- National Science Foundation [IOS-1339209]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1339209] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1158262] Funding Source: National Science Foundation
To reduce crop losses due to geminivirus infection, we targeted the bean yellow dwarf virus (BeYDV) genome for destruction with the CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) system. Transient assays using BeYDV-based replicons revealed that CRISPR-Cas reagents introduced mutations within the viral genome and reduced virus copy number. Transgenic plants expressing CRISPR-Cas reagents and challenged with BeYDV had reduced virus load and symptoms, thereby demonstrating a novel strategy for engineering resistance to geminiviruses.
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