期刊
NEUROIMAGE-CLINICAL
卷 5, 期 -, 页码 359-364出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2014.07.004
关键词
Hippocampus; Cerebral blood volume; Schizophrenia; CA1; CA2/3; CBV
类别
资金
- [R01 MH070567]
- [R01 NS078828F30]
- [F30 MH102846]
- [T32 GM07347]
- [UR1 TR000445]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000445] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007347] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [F30MH102846, R01MH070560] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS078828] Funding Source: NIH RePORTER
Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p =.06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations. (C) 2014 The Authors. Published by Elsevier Inc.
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