期刊
LANCET RESPIRATORY MEDICINE
卷 2, 期 11, 页码 919-932出版社
ELSEVIER SCI LTD
DOI: 10.1016/S2213-2600(14)70169-9
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资金
- Centocor
- Sanofi Pasteur
- GlaxoSmithKline
- Chiesi
- Boehringer Ingelheim
- Novartis
- Grunenthal
- Synairgen
- MRC [G0600879, G0601236] Funding Source: UKRI
- Asthma UK [MRC-AsthmaUKCentre] Funding Source: researchfish
- Medical Research Council [G1000758B, G1000758] Funding Source: researchfish
- National Institute for Health Research [ACF-2012-21-016, CL-2008-21-014] Funding Source: researchfish
Inhaled corticosteroids are widely used in chronic obstructive pulmonary disease (COPD) and, in combination with long-acting beta(2) agonists, reduce exacerbations and improve lung function and quality of life. However, inhaled corticosteroids have been linked with an increased risk of pneumonia in individuals with COPD, but the magnitude of this risk, the effects of different preparations and doses, and the mechanisms of this effect remain unclear. Therefore, making informed clinical decisions balancing the beneficial and adverse effects of inhaled corticosteroids in individuals with COPD-is difficult. Understanding of the mechanisms of increased pneumonia risk with inhaled corticosteroids is urgently needed to clarify their role in the management of COPD and to aid the development of new, safer therapies.
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