期刊
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
卷 -, 期 59, 页码 -出版社
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/3638
关键词
Neuroscience; Issue 59; animal models; behavioral analysis; neuroscience; neurobiology; mood disorder; depression; mood stabilizer; antidepressant; forced swimming test; FST
资金
- NIHM [R01 MH091816, R21 MH084043]
The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straightforward to conduct reliably and it requires minimal specialized equipment. Successful implementation of the forced swim test requires adherence to certain procedural details and minimization of unwarranted stress to the mice. In the protocol description and the accompanying video, we explain how to conduct the mouse version of this test with emphasis on potential pitfalls that may be detrimental to interpretation of results and how to avoid them. Additionally, we explain how the behaviors manifested in the test are assessed.
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