期刊
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
卷 -, 期 56, 页码 -出版社
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/3159
关键词
Developmental Biology; Issue 56; mesenchymal stem cell; MSC; lung stem cell; resident lung mesenchymal stem cells; stem cells
资金
- AHA [GIA0855953G]
- NIH [1R01 HL091105-01, RO1DK075013]
- Kleberg Foundation
- UCCC Flow Cytometry Core [NIH 5 P30 CA 46934-15]
- UCCC Microarray core [NCI P30 CA 46934-14]
Tissue resident mesenchymal stem cells (MSC) are important regulators of tissue repair or regeneration, fibrosis, inflammation, angiogenesis and tumor formation. Taken together these studies suggest that resident lung MSC play a role during pulmonary tissue homeostasis, injury and repair during diseases such as pulmonary fibrosis (PF) and arterial hypertension (PAH). Here we describe a technology to define a population of resident lung MSC. The definition of this population in vivo pulmonary tissue using a define set of markers facilitates the repeated isolation of a well-characterized stem cell population by flow cytometry and the study of a specific cell type and function.
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