期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/476068
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类别
资金
- Ministry of Education, Youth and Sports, Czech Republic [PRVOUK-P28/LF1/6]
- Internal Grant Agency, Ministry of Health, Czech Republic [NT 13087-3, NT 14164-3]
Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacteriumis a naturalmember of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens- Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the red complex, a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.
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