期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/297073
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资金
- Deutsche Forschungsgemeinschaft (DFG)
HLA-Gis a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.
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