期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 37, 期 6, 页码 503-509出版社
SPRINGER
DOI: 10.1007/s40618-013-0045-6
关键词
Metabolic syndrome; Endothelial dysfunction; Oxidative stress; Gestational diabetes mellitus; Postpartum
资金
- Andalusia Department of Health [CTS-368]
Relationships between adhesion molecules (AM), oxidative stress, gestational diabetes mellitus (GDM) and future development of type 2 diabetes mellitus are unclear. We investigated AM and oxidant/antioxidant markers in women with previous history of GDM. Postpartum women with GDM (cases; n = 41) and healthy women (controls; n = 21) had clinical and laboratory variables measured, including indicators of vascular damage (ICAM-1, VCAM-1 and E-selectin), oxidative stress (LPO, GSH and GST) and antioxidant markers (catalase, SOD, GPX and TAC). Previous GDM versus control women presented higher body mass index: 27.4 +/- A 5.6 versus 23.9 +/- A 3.6 (p = 0.013); waist circumference: 85.2 +/- A 12.9 versus 77.5 +/- A 9.0 (p = 0.017); MetS (WHO definition): 14.6 versus 0 % (p = 0.012); MetS (NCEP-ATPIII definition): 22 versus 0 % (p = 0.002); low HDL: 36.6 versus 9.5 % (p = 0.024); fasting glucose (mmol/L): 5.4 +/- A 0.6 versus 4.9 +/- A 0.2 (p < 0.001); glucose 120 min (mg/dL): 105.0 +/- A 30.2 versus 85.1 +/- A 14.2 (p = 0.007); fasting insulin (mu U/mL): 13.4 +/- A 8.1 versus 8.4 +/- A 4.3 (p = 0.004); HOMA index: 3.3 +/- A 2.3 versus 1.8 +/- A 1.0 (p = 0.002); HbA1c (%/mmol/mol): 5.4 +/- A 0.2 versus 5.2 +/- A 0.2/36 +/- A 1.4 versus 33 +/- A 1.4 (p = 0.021); uric acid (mg/dL): 4.1 +/- A 1 versus 3.5 +/- A 0.6 (p = 0.009); catalase (nmol/min/mL): 38.7 +/- A 15.6 versus 28.9 +/- A 11.1 (p = 0.013). There were no significant differences in hypertension prevalence, lipid fractions, albumin/creatinine ratio and AM. Women with previous GDM have high catalase levels which correlate positively with glucose intolerance, indicating the potential effect of oxidative stress on postpartum dysglycemic status.
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