期刊
JOURNAL OF CO2 UTILIZATION
卷 27, 期 -, 页码 366-373出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcou.2018.08.015
关键词
Supercritical antisolvent coprecipitation; Drug release; Microparticles; Nanoparticles; Zein; SAS characteristic times
资金
- Italian Ministry of Scientific Research
In this work, the supercritical antisolvent (SAS) process is proposed to coprecipitate zein with diclofenac sodium (a model drug). In the first part of this paper, the proper conditions, in terms of pressure, temperature and concentration, for the attainment of zein microparticles, were detected. At 90 bar, 40 degrees C and 50 mg/mL, microparticles with a mean diameter of 4.19 mu m were obtained. The coprecipitation with diclofenac sodium at different polymer/drug ratio and concentration in the liquid solution was successfully performed and, with the support of the drug release analyses, the coprecipitation mechanisms (both in the case of microparticles and nanoparticles formation) were postulated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据