期刊
GENES
卷 5, 期 1, 页码 147-175出版社
MDPI
DOI: 10.3390/genes5010147
关键词
ATR; DNA replication fork arrest; DNA replication stress; DNA damage; single-stranded DNA
资金
- Fondation ARC pour la Recherche sur le Cancer
- Ligue contre le cancer
- EDF
- ANR
The major challenge of the cell cycle is to deliver an intact, and fully duplicated, genetic material to the daughter cells. To this end, progression of DNA synthesis is monitored by a feedback mechanism known as replication checkpoint that is untimely linked to DNA replication. This signaling pathway ensures coordination of DNA synthesis with cell cycle progression. Failure to activate this checkpoint in response to perturbation of DNA synthesis (replication stress) results in forced cell division leading to chromosome fragmentation, aneuploidy, and genomic instability. In this review, we will describe current knowledge of the molecular determinants of the DNA replication checkpoint in eukaryotic cells and discuss a model of activation of this signaling pathway crucial for maintenance of genomic stability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据