期刊
GENES
卷 5, 期 4, 页码 926-956出版社
MDPI
DOI: 10.3390/genes5040926
关键词
microRNA; diabetes; macrovascular and microvascular complications; skin; wound healing; inflammation; vascular disease; diagnostic biomarkers; therapeutic targets
资金
- FEDER funds by the operational program Factors of Competitivity-COMPETE
- Portuguese Foundation for Science and Technology (Eugenia Carvalho) [EXCL/DTP-PIC/0069/2012, PEst-C/SAU/LA0001/2013]
- Grupo de Estudo de Investigacao Fundamental e Translacional/Sociedade Portuguesa de Diabetologia
- Arkansas Biosciences Institute
- major research component of the Arkansas Tobacco Settlement Proceeds Act of (Elisabet Borsheim and Eugenia Carvalho)
- [P30 AG028718]
- Fundação para a Ciência e a Tecnologia [EXCL/DTP-PIC/0069/2012] Funding Source: FCT
Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing.
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