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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TopBP1 activates the ATR-ATRIP complex
A Kumagai et al.
CELL (2006)
Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1
JL Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling
M Clerici et al.
EMBO REPORTS (2006)
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
MC Keogh et al.
NATURE (2006)
Cdc25: mechanisms of checkpoint inhibition and recovery
Christina Karisson-Rosenthal et al.
TRENDS IN CELL BIOLOGY (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations
JA Cobb et al.
GENES & DEVELOPMENT (2005)
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks
E Itakura et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
M Clerici et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP
SM Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage
D Nakada et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9
R Wysocki et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
HL Ball et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mrc1 is required for normal progression of replication forks throughout chromatin in S-cerevisiae
SJ Szyjka et al.
MOLECULAR CELL (2005)
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53
H Tourrière et al.
MOLECULAR CELL (2005)
High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae
JM Bean et al.
GENETICS (2005)
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation
FD Sweeney et al.
CURRENT BIOLOGY (2005)
Checkpoint responses to replication fork barriers
S Lambert et al.
BIOCHIMIE (2005)
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
XB Lu et al.
GENES & DEVELOPMENT (2005)
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
HL Ball et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
TS Byun et al.
GENES & DEVELOPMENT (2005)
Replication checkpoint kinase Cds1 regulates Mus81 to reserve genome integrity during replication stress
M Kai et al.
GENES & DEVELOPMENT (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
VG Gorgoulis et al.
NATURE (2005)
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
A Traven et al.
BIOESSAYS (2005)
Evidence that DNA damage detection machinery participates in DNA repair
CE Helt et al.
CELL CYCLE (2005)
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1
M Giannattasio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Temporal separation of replication and recombination requires the intra-S checkpoint
P Meister et al.
JOURNAL OF CELL BIOLOGY (2005)
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
CS Sorensen et al.
NATURE CELL BIOLOGY (2005)
Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance
L Bjergbaek et al.
EMBO JOURNAL (2005)
Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe
DY Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells
C Cotta-Ramusino et al.
MOLECULAR CELL (2005)
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
C Lundin et al.
NUCLEIC ACIDS RESEARCH (2005)
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
NR den Elzen et al.
EMBO JOURNAL (2004)
Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing
C Lucca et al.
ONCOGENE (2004)
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
SL Davies et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication
M Pacek et al.
EMBO JOURNAL (2004)
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
H van Attikum et al.
CELL (2004)
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
HY Yoo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior
V Krishnan et al.
MOLECULAR CELL (2004)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
D Cortez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation
SJ Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1
WS Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
A Kumagai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
AA Goodarzi et al.
EMBO JOURNAL (2004)
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase β and increases its DNA substrate utilisation efficiency:: implications for DNA repair
M Toueille et al.
NUCLEIC ACIDS RESEARCH (2004)
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BCRT domains of Rad4TOPBP1
K Furuya et al.
GENES & DEVELOPMENT (2004)
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
Y Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
JP Jin et al.
GENES & DEVELOPMENT (2003)
Building and breaking bridges between sister chromatids
CH Haering et al.
BIOESSAYS (2003)
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents
JS Liu et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
L Busino et al.
NATURE (2003)
Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling
SJ Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The checkpoint protein Rad24 of Saccharomyces cerevisiae is involved in processing double-strand break ends and in recombination partner choice
Y Aylon et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
Y Katou et al.
NATURE (2003)
Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation
BL Pike et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1
JA Cobb et al.
EMBO JOURNAL (2003)
Human claspin is required for replication checkpoint control
C Christiano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
AJ Osborn et al.
GENES & DEVELOPMENT (2003)
Identification of MCM4 as a target of the DNA replication block checkpoint system
Y Ishimi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage
C Redon et al.
EMBO REPORTS (2003)
Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links
S Lambert et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments
X Veaute et al.
NATURE (2003)
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
L Krejci et al.
NATURE (2003)
A central role for DNA replication forks in checkpoint activation and response
JA Tercero et al.
MOLECULAR CELL (2003)
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle
P Pichierri et al.
ONCOGENE (2003)
PP2C Phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break
C Leroy et al.
MOLECULAR CELL (2003)
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
A Chabes et al.
CELL (2003)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
Checkpoint activation regulates mutagenic translesion synthesis
M Kai et al.
GENES & DEVELOPMENT (2003)
FHA Domain-Mediated DNA Checkpoint Regulation of Rad53
Marc F. Schwartz et al.
CELL CYCLE (2003)
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase
K Shimada et al.
GENES & DEVELOPMENT (2002)
ATR regulates fragile site stability
AM Casper et al.
CELL (2002)
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase
MB Vaze et al.
MOLECULAR CELL (2002)
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
RS Cha et al.
SCIENCE (2002)
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
JM Sogo et al.
SCIENCE (2002)
Dot1p modulates silencing in yeast by methylation of the nucleosome core
F van Leeuwen et al.
CELL (2002)
Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
MF Schwartz et al.
MOLECULAR CELL (2002)
The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor SmI1
XL Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Regulation of the Bub2/Bfal GAP complex by Cdc5 and cell cycle checkpoints
FH Hu et al.
CELL (2001)
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
K Koniaras et al.
ONCOGENE (2001)
Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
K Tanaka et al.
NATURE CELL BIOLOGY (2001)
Structure and function of the radical enzyme ribonucleotide reductase
H Eklund et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2001)
Mrc1 transduces signals of DNA replication stress to activate Rad53
AA Alcasabas et al.
NATURE CELL BIOLOGY (2001)
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p
AP Gasch et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
The yeast Xrs2 complex functions in S phase checkpoint regulation
D D'Amours et al.
GENES & DEVELOPMENT (2001)
The DNA replication checkpoint response stabilizes stalled replication forks
M Lopes et al.
NATURE (2001)
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
JA Tercero et al.
NATURE (2001)
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
XL Zhao et al.
EMBO JOURNAL (2001)
Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
CS Gilbert et al.
MOLECULAR CELL (2001)
Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
V Costanzo et al.
MOLECULAR CELL (2001)
Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis
DJ Clarke et al.
NATURE CELL BIOLOGY (2001)
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway
V Paciotti et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae
HS Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Threonine-11, phosphorylated by Rad3 and ATM in vitro, is required for activation of fission yeast checkpoint kinase Cds1
K Tanaka et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
KJ Myung et al.
CELL (2001)
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
VR Iyer et al.
NATURE (2001)
A role for Saccharomyces cerevisiae histone H2A in DNA repair
JA Downs et al.
NATURE (2000)
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
GS Brush et al.
NUCLEIC ACIDS RESEARCH (2000)
Activation of the DNA replication checkpoint through RNA synthesis by primase
WM Michael et al.
SCIENCE (2000)
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
S Matsuoka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A chromatin remodelling complex involved in transcription and DNA processing
XT Shen et al.
NATURE (2000)
Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
D Strumberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
A de Klein et al.
CURRENT BIOLOGY (2000)
FAT: a novel domain in PIK-related kinases
R Bosotti et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
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