期刊
GENES
卷 2, 期 1, 页码 1-20出版社
MDPI
DOI: 10.3390/genes2010001
关键词
Non-allelic (ectopic) gene conversion; gene duplication; illegitimate recombination; angiosperm; grass
资金
- US National Science Foundation [MCB-1021718]
- J. S. Guggenheim Foundation
- China National Science Foundation [30971611]
- China-Hebei New Century 100 Creative Talents Project
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0817707] Funding Source: National Science Foundation
Angiosperm genomes differ from those of mammals by extensive and recursive polyploidizations. The resulting gene duplication provides opportunities both for genetic innovation, and for concerted evolution. Though most genes may escape conversion by their homologs, concerted evolution of duplicated genes can last for millions of years or longer after their origin. Indeed, paralogous genes on two rice chromosomes duplicated an estimated 60-70 million years ago have experienced gene conversion in the past 400,000 years. Gene conversion preserves similarity of paralogous genes, but appears to accelerate their divergence from orthologous genes in other species. The mutagenic nature of recombination coupled with the buffering effect provided by gene redundancy, may facilitate the evolution of novel alleles that confer functional innovations while insulating biological fitness of affected plants. A mixed evolutionary model, characterized by a primary birth-and-death process and occasional homoeologous recombination and gene conversion, may best explain the evolution of multigene families.
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