期刊
FRONTIERS IN PHYSIOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fphys.2014.00088
关键词
pancreatic cancer; cachexia; anorexia; catabolism; multimodal therapy
类别
资金
- NCI NIH HHS [P01 CA163200] Funding Source: Medline
- NIDDK NIH HHS [P01 DK098108] Funding Source: Medline
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
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