期刊
FRONTIERS IN PHYSIOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fphys.2014.00141
关键词
pancreatic cancer; chemoresistance; pancreatic stellate cells; stroma; fibrosis; hypoxia
类别
资金
- National Health and Medical Research Council (NHMRC)
- Cancer Council New South Wales
- Cure Cancer Australia Foundation Grant
- Cancer Institute New South Wales Career Development Fellowship
- NHMRC Career Development Fellowship
- NHMRC Senior Research Fellowship
- University of New South Wales Goldstar Award
Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.
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