期刊
FRONTIERS IN PHYSIOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2012.00081
关键词
Notch; vascular smooth muscle; signaling
类别
资金
- Graduate School of Biomedical Sciences at University of Maine, Orono
- Founders Affiliate of the American Heart Association [10PRE3680003]
- March of Dimes grant [FY10-496, R01 HD034883]
- [R01 HL070865]
Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and responds to Notch ligands as a regulatory mechanism of differentiation, recruitment to growing vessels, and maturation. The goal of this review is to provide an overview of the current understanding of the molecular basis for Notch regulation of VSMC phenotype. Further, we will explore Notch interaction with other signaling pathways important in VSMC.
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