期刊
FRONTIERS IN PHARMACOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2014.00012
关键词
GABA(B) receptor; dimers; large oligomers; G-protein coupled receptor interacting proteins; signal transduction
资金
- National Natural Science Foundation of China (NSFC) [31130028, 31225011]
- Ministry of Science and Technology [2012CB518000]
- Program of Introducing Talents of Discipline to the Universities of the Ministry of Education [B08029]
- Merieux Research Grants Program of Institut Merieux
- CNRS
- INSERM
- ANR [ANR-12-BSV2-0015-01]
- FRM [FRM DEQ20130326522]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV2-0015] Funding Source: Agence Nationale de la Recherche (ANR)
The main inhibitory neurotransmitter, GABA, acts on both ligand-gated and G protein-coupled receptors, the GABA(A/C) and GABA(B) receptors, respectively. The later play important roles in modulating many synapses, both at the pre- and post-synaptic levels, and are then still considered as interesting targets to treat a number of brain diseases, including addiction. For many years, several subtypes of GABA(B) receptors were expected, but cloning revealed only two genes that work in concert to generate a single type of GABA(B) receptor composed of two subunits. Here we will show that the signaling complexity of this unit receptor type can be largely increased through various ways, including receptor stoichiometry, subunit isoforms, cell-surface expression and localization, crosstalk with other receptors, or interacting proteins. These recent data revealed how complexity of a receptor unit can be increased, observation that certainly are not unique to the GABAB receptor.
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