相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model
K. Melissa Hallow et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2014)
Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury
Lisl K. M. Shoda et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2014)
Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development
P. A. Milligan et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Activation of GPR40 as a Therapeutic Target for the Treatment of Type 2 Diabetes
Charles F. Burant
DIABETES CARE (2013)
The beneficial effect of metformin on β-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes
Y. Bi et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2013)
Mechanistic systems modeling to guide drug discovery and development
Brian J. Schmidt et al.
DRUG DISCOVERY TODAY (2013)
Model-based drug discovery: implementation and impact
Sandra A. G. Visser et al.
DRUG DISCOVERY TODAY (2013)
Fasiglifam as a new potential treatment option for patients with type 2 diabetes
Kohei Kaku
EXPERT OPINION ON PHARMACOTHERAPY (2013)
A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1
Chiori Yabuki et al.
PLOS ONE (2013)
The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
Arturo D. Mancini et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System
S. Schaller et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2013)
The impact of mathematical modeling on the understanding of diabetes and related complications
I. Ajmera et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2013)
A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes
E. Leifke et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Properties of the GPR40 Agonist TAK-875: Results From a Double-Blind, Placebo-Controlled Single Oral Dose Rising Study in Healthy Volunteers
Himanshu Naik et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2012)
A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents
Jian Luo et al.
PLOS ONE (2012)
Clinical Pharmacokinetics of Metformin
Garry G. Graham et al.
CLINICAL PHARMACOKINETICS (2011)
Software for systems biology: from tools to integrated platforms
Samik Ghosh et al.
NATURE REVIEWS GENETICS (2011)
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks
Thomas Eissing et al.
FRONTIERS IN PHYSIOLOGY (2011)
HumMod: a modeling environment for the simulation of integrative human physiology
Robert L. Hester et al.
FRONTIERS IN PHYSIOLOGY (2011)
DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results
Nail M. Gizzatkulov et al.
BMC SYSTEMS BIOLOGY (2010)
The Type 1 Diabetes PhysioLab® Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
L. Shoda et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)
Glucose Control by the Kidney: An Emerging Target in Diabetes
Olivera Marsenic
AMERICAN JOURNAL OF KIDNEY DISEASES (2009)
Kidney modeling and systems physiology
S. Randall Thomas
Wiley Interdisciplinary Reviews-Systems Biology and Medicine (2009)
Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology
Albert A. de Graaf et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Glucokinase and molecular aspects of liver glycogen metabolism
Loranne Agius
BIOCHEMICAL JOURNAL (2008)
Metformin and the intestine
C. J. Bailey et al.
DIABETOLOGIA (2008)
SAPHIR:: a physiome core model of body fluid homeostasis and blood pressure regulation
S. Randall Thomas et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2008)
Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic β-cell:: a computational approach
Leonid E. Fridlyand et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Stochastic simulation GUI for biochemical networks
Ravishankar Rao Vallabhajosyula et al.
BIOINFORMATICS (2007)
Insulin granule trafficking in β-cells:: mathematical model of glucose-induced insulin secretion
Alessandro Bertuzzi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Model-based drug development
R. L. Lalonde et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Short-term effects of metformin in type 2 diabetes
A. Eriksson et al.
DIABETES OBESITY & METABOLISM (2007)
Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes - results of a hyperglycaemic glucose clamp study
Klaus Rave et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)
Systems biology for battling rheumatoid arthritis: Application of the Entelos PhysioLab platform
JAC Rullmann et al.
IEE PROCEEDINGS SYSTEMS BIOLOGY (2005)
Regulation of pancreatic beta-cell mass
L Bouwens et al.
PHYSIOLOGICAL REVIEWS (2005)
Using process diagrams for the graphical representation of biological networks
H Kitano et al.
NATURE BIOTECHNOLOGY (2005)
Use and abuse of HOMA modeling
TM Wallace et al.
DIABETES CARE (2004)
Diversity of mechanism-based pharmacodynamic models
DE Mager et al.
DRUG METABOLISM AND DISPOSITION (2003)
Metformin: An update
D Kirpichnikov et al.
ANNALS OF INTERNAL MEDICINE (2002)
Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis
J Radziuk et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2001)
Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose -: A direct metformin effect on pancreatic β-cells
G Patanè et al.
DIABETES (2000)