期刊
FRONTIERS IN PHARMACOLOGY
卷 1, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2010.00116
关键词
prostaglandin F2alpha; hypertension; atherosclerosis; FP receptor
资金
- Chinese Academy of Sciences [O914X41281, 2010OHTP10]
- Clinic Research Center at Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences [CRC2010007]
- Ministry of Science and Technology of China [2011CB503906]
Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation and cardiovascular homeostasis. Each PG acts on its specific and distinct cell surface G protein-coupled receptors (GPCRs) or peroxisome proliferator-activated receptors (PPARs). Prostaglandin F-2 alpha receptor (FP) is required for female reproductive function such as luteolysis and parturition. It has recently been implicated in blood pressure regulation, atherosclerosis and other inflammation-related disorders. The emerging role of FP in cardiovascular diseases is highlighted and potential therapeutic translation is discussed in the current review.
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