期刊
FRONTIERS IN NEUROSCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2018.00527
关键词
micronutrients; vitamins; magnesium; presbycusis; aging; hearing loss; age-related hearing loss; auditory brainstem response
资金
- Ministerio de Economia y Competitividad (MINECO), Programa Estatal de I+D+I [SAF 2016 78898 C2-1-R]
- PROHEARING project of the 7th Framework Program [FP7-HEALTH-2012-INNOVATON 304925]
The increasing rate of age-related hearing loss (ARHL), with its subsequent reduction in quality of life and increase in health care costs, requires new therapeutic strategies to reduce and delay its impact. The goal of this study was to determine if ARHL could be reduced in a rat model by administering a combination of antioxidant vitamins A, C, and E acting as free radical scavengers along with Mg++, a known powerful cochlear vasodilator (ACEMg). Toward this goal, young adult, 3 month-old Wistar rats were divided into two groups: one was fed with a diet composed of regular chow (normal diet, ND); the other received a diet based on chow enriched in ACEMg (enhanced diet, ED). The ED feeding began 10 days before the noise stimulation. Auditory brainstem recordings (ABR) were performed at 0.5, 1,2, 4, 8, 16, and 32 kHz at 3,6-8, and 12-14 months of age. No differences were observed at 3 months of age, in both ND and ED animals At 6-8 and 12-14 months of age there were significant increases in auditory thresholds and a reduction in the wave amplitudes at all frequencies tested, compatible with progressive development of ARHL However, at 6-8 months threshold shifts in ED rats were significantly lower in low and medium frequencies, and wave amplitudes were significantly larger at all frequencies when compared to ND rats. In the oldest animals, differences in the threshold shift persisted, as well as in the amplitude of the wave II, suggesting a protective effect of ACEMg on auditory function during aging. These findings indicate that oral ACEMg may provide an effective adjuvant therapeutic intervention for the treatment of ARHL, delaying the progression of hearing impairment associated with age.
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