期刊
FRONTIERS IN NEUROSCIENCE
卷 3, 期 3, 页码 337-343出版社
FRONTIERS MEDIA SA
DOI: 10.3389/neuro.01.030.2009
关键词
motor; frontal; synaptic circuits; pyramidal neuron
资金
- Brain Research Foundation
- Howard Hughes Medical Institute
- International Rett Syndrome Foundation
- National Institutes of Health (NINDS) [NS061963]
- Simons Foundation
- Whitehall Foundation
A well-defined granular layer 4 is a defining cytoarchitectonic feature associated with sensory areas of mammalian cerebral cortex, and one with hodological significance: the local axons ascending from cells in thalamorecipient layer 4 and connecting to layer 2/3 pyramidal neurons form a major feedforward excitatory interlaminar projection. Conversely, agranular cortical areas, lacking a distinct layer 4, pose a hodological conundrum: without a laminar basis for the canonical layer 4 -> 2/3 pathway, what is the basic circuit organization? This review highlights current challenges and prospects for local-circuit electroanatomy and electrophysiology in agranular cortex, focusing on the mouse. Different lines of evidence, drawn primarily from studies of motor areas in frontal cortex in rodents, support the view that synaptic circuits in agranular cortex are organized around prominent descending excitatory layer 2/3 -> 5 pathways targeting multiple classes of projection neurons.
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