4.5 Article

Optogenetic deconstruction of sleep-wake circuitry in the brain

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/neuro.02.031.2009

关键词

hypothalamus; sleep; wakefulness; optogenetics; hypocretins/orexins

资金

  1. Fonds National de la Recherche Scientifique (Charge de Recherche)
  2. NIH (K99)
  3. NARSAD
  4. National Science Foundation
  5. National Institutes of Health [F31MH83439]
  6. National Institute on Drug Abuse, Defense Advanced Research Projects Agency
  7. National Alliance for Research on Schizophrenia and Depression

向作者/读者索取更多资源

How does the brain regulate the sleep-wake cycle? What are the temporal codes of sleep- and wake-promoting neural circuits? How do these circuits interact with each other across the light/dark cycle? Over the past few decades, many studies from a variety of disciplines have made substantial progress in answering these fundamental questions. For example, neurobiologists have identified multiple, redundant wake-promoting circuits in the brainstem, hypothalamus, and basal forebrain. Sleep-promoting circuits have been found in the preoptic area and hypothalamus. One of the greatest challenges in recent years has been to selectively record and manipulate these sleep-wake centers in vivo with high spatial and temporal resolution. Recent developments in microbial opsin-based neuromodulation tools, collectively referred to as optogenetics, have provided a novel method to demonstrate causal links between neural activity and specific behaviors. Here, we propose to use optogenetics as a fundamental tool to probe the necessity, sufficiency, and connectivity of defined neural circuits in the regulation of sleep and wakefulness.

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