期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/neuro.02.009.2009
关键词
glycine receptor; cytoprotection; glia; immune cells; renal cells; hepatocytes; endothelial cells
资金
- FWO (Fonds voor Wetenschappelijk Onderzoek) Flanders
- Belgian IAP(Interuniversitary Attraction Pole)
- BOF (Bijzonder Onderzoeksfonds) Hasselt University
- Medical Research Council [G0500833]
- MRC [G0601585, G0500833] Funding Source: UKRI
Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types. Modulatory effects were mainly described in immune cells, endothelial cells and macroglial cells, where glycine modulates proliferation, differentiation, migration and cytokine production. Activation of glycine receptors (GlyRs) causes membrane potential changes that in turn modulate calcium flux and downstream effects in these cells. Cytoprotective effects were mainly described in renal cells, hepatocytes and endothelial cells, where glycine protects cells from ischemic cell death. In these cell types, glycine has been suggested to stabilize porous defects that develop in the plasma membranes of ischemic cells, leading to leakage of macromolecules and subsequent cell death. Although there is some evidence linking these effects to the activation of GlyRs, they seem to operate in an entirely different mode from classical neuronal subtypes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据