期刊
FEBS OPEN BIO
卷 4, 期 -, 页码 755-762出版社
WILEY
DOI: 10.1016/j.fob.2014.08.003
关键词
Quercetin; Proprotein convertase; Low-density lipoprotein receptor; Cholesterol; Sortilin; Hepatocytes
资金
- Canadian Institute of Heath Research
- Edith and Richard Strauss Foundation
- La Foundation J.-Louis Levesque
Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation. The plant flavonoid quercetin-3-beta-D-glucoside (Q3G) has been shown to reduce hypercholesterolemia in experimental animals. Here, we examined how it affects LDLR and PCSK9 expression as well as LDL uptake by human Huh7 hepatocytes. At low micromolar concentrations, Q3G increased LDLR expression, reduced PCSK9 secretion, and stimulated LDL uptake. It also diminished intracellular sortilin, a sorting receptor known to facilitate PCSK9 secretion. Thus, as an LDLR inducer and a PCSK9 anti-secretagogue, Q3G may represent an effective anti-cholesterolemic agent. (C) 2014 The Authors. Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
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