期刊
FEBS OPEN BIO
卷 4, 期 -, 页码 175-178出版社
WILEY
DOI: 10.1016/j.fob.2014.01.010
关键词
Ribosome; Peptidyl Transferase Center; Origin; tRNA
资金
- UNAM, Mexico [PAPIIT-IN107112]
We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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