期刊
FEBS OPEN BIO
卷 3, 期 -, 页码 41-45出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.fob.2012.11.002
关键词
iODN; Class I iODN; Class II iODN; Class I/II hybrid iODN; immunosuppression
资金
- Japan Society for the Promotion of Science (JSPS) [24580388]
- Mishima Kaiun Memorial Foundation
- Grants-in-Aid for Scientific Research [23790917, 24580388] Funding Source: KAKEN
We designed class I/II hybrid inhibitory oligodeoxynucleotides (iODNs), called iSG, and found that the sequence 5'-TTAGGG-3', which has a six-base loop head structure, and a 3'-oligo (dG)(3-5) tail sequence are important for potent immunosuppressive activity. Interestingly, splenocytes isolated from ovalbumin (OVA)-immunized mice and treated with iSG3 showed suppression of not only interleukin (IL)-6, IL-12p35, IL-12p40, and interferon (IFN) gamma mRNA expression, but also IL-4 and IL-13 mRNA expression. Thus, both Th2 and Th1 immune responses can be strongly suppressed by iODNs in splenocytes from allergen-immunized mice, suggesting usefulness in the treatment of diseases induced by over-active immune activation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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