期刊
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
卷 7, 期 6, 页码 837-846出版社
INFORMA HEALTHCARE
DOI: 10.1586/17512433.2014.966816
关键词
cancer metabolism; chemotherapy; lipoate; lipoate analogs; lipoic acid; lipoic acid analogs; tumor mitochondria; two compartment metabolism
资金
- Cornerstone Pharmaceuticals
- Cornerstone Pharmaceuticals, Inc.
The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix, ultimately functioning to control these metabolic fluxes. Moreover, these lipoate-sensitive regulatory processes are apparently systematically redesigned in tumor cells and the affected enzymes commonly become especially central to cancer metabolism. Thus, lipoate-sensitive regulatory processes constitute potentially uniquely valuable targets for chemotherapeutic attack. Our goal here is to review the current status of our knowledge relevant to the use of lipoate and lipoate analogs to therapeutically attack malignant disease.
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