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AUTOPHAGY (2014)
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Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells
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Birt-Hogg-Dube syndrome and the skin
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Lambros Stamatakis et al.
FAMILIAL CANCER (2013)
Pulmonary manifestations of Birt-Hogg-Dube syndrome
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FAMILIAL CANCER (2013)
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
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JOURNAL OF CELL BIOLOGY (2013)
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
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AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2012)
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development
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BLOOD (2012)
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA
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DNA REPAIR (2012)
Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis
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HUMAN MOLECULAR GENETICS (2012)
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
Heon Park et al.
IMMUNITY (2012)
Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)
Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
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PLOS ONE (2012)
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
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SCIENCE SIGNALING (2012)
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer
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Renal cancer and pneumothorax risk in Birt-Hogg-Dube syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families
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BRITISH JOURNAL OF CANCER (2011)
Constitutional FLCN mutations in patients with suspected Birt-Hogg-Dube syndrome ascertained for non-cutaneous manifestations
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CLINICAL GENETICS (2011)
Identification of Intragenic Deletions and Duplication in the FLCN Gene in Birt-Hogg-Dube Syndrome
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GENES CHROMOSOMES & CANCER (2011)
Birt Hogg-Dube Syndrome-Associated FLCN Mutations Disrupt Protein Stability
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HUMAN MUTATION (2011)
Therapeutic Targeting the Loss of the Birt-Hogg-Dube Suppressor Gene
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MOLECULAR CANCER THERAPEUTICS (2011)
Absence of the Birt-Hogg-Dube gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility
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ONCOGENE (2011)
Loss of the Birt-Hogg-Dube tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription
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ONCOGENE (2011)
Birt-Hogg-Dube renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression
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Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product
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FEBS LETTERS (2010)
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HUMAN MUTATION (2010)
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JOURNAL OF MEDICAL GENETICS (2010)
Investigation of the Birt-Hogg-Dube tumour suppressor gene (FLCN) in familial and sporadic colorectal cancer
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JOURNAL OF MEDICAL GENETICS (2010)
Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature
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Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
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ONCOGENE (2008)
Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia
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Mutations of the Birt-Hogg-Dube gene in patients with multiple lung cysts and recurrent pneumothorax
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The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cystic lung disease in Birt-Hogg-Dube syndrome
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CHEST (2007)
Lung cysts, spontaneous pneumothorax, and genetic associations in 89 families with Birt-Hogg-Dube syndrome
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dube patients
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)
Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
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Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
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Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)
High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dube-associated renal tumors
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JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
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A 4-bp deletion in the Birt-Hogg-Dube gene (FLCN) causes dominantly inherited spontaneous pneumothorax
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Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma
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Clinical and genetic studies of Birt-Hogg-Dube syndrome
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JOURNAL OF MEDICAL GENETICS (2002)
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome
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CANCER CELL (2002)
Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2
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AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Parotid oncocytoma in the Birt-Hogg-Dube syndrome
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JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2000)
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