期刊
EMERGING MICROBES & INFECTIONS
卷 7, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1038/s41426-018-0144-8
关键词
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资金
- Wellcome Trust Investigator Award [100974/C/13/Z]
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Institute Strategic Programme Gut Microbes and Health [BB/R012490/1]
- Institute Strategic Programme Gut Health and Food Safety [BB/J004529/1]
- University of East Anglia International Bursary (Faculty of Medical and Health Sciences)
- BBSRC [BBS/E/F/00044409, BBS/E/F/000PR10353, BBS/E/F/000PR10356] Funding Source: UKRI
Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of > 20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century. Recent advances in genomic analysis and experimental systems make it timely to re-visit this clinically and veterinary important pathogen. This Review will summarise our understanding of the genomics and virulence-linked factors, including antimicrobial potentials and secreted toxins of this gut pathogen, and then its up-to-date clinical epidemiology and biological role in the pathogenesis of several important human and animal-associated intestinal diseases, including pre-term necrotising enterocolitis. Finally, we highlight some of the important unresolved questions in relation to C. perfringens-mediated infections, and implications for future research directions.
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