期刊
CURRENT UROLOGY REPORTS
卷 13, 期 2, 页码 179-186出版社
SPRINGER
DOI: 10.1007/s11934-012-0240-6
关键词
Prostate cancer; Radical prostatectomy; High-risk prostate cancer; Outcomes; Adjuvant; Radiotherapy; Adjuvant hormone therapy; Treatment; Combination therapy; Gleason score; Staging; Radical prostatectomy
High-risk prostate cancer (PCa), established according to the d'Amico criteria or other prognostic tools, remains very heterogeneous, including a third of patients with excellent prognosis in whom surgical treatment can result in long-term progression-free survival. In contrast, a substantial proportion of high risk will not be cured by local treatment alone and might benefit from a more aggressive multimodal adjuvant treatment strategy. However, to date, except in one adjuvant radiotherapy series, no neoadjuvant or adjuvant therapy has shown a survival improvement after radical prostatectomy for high-risk PCa. Recent observational studies tend to prove that radical prostatectomy may offer benefits over radiotherapy in disease-free and overall survival. However, good Level 1 evidence is lacking and further prospective studies are warranted to directly compare the outcomes of radical prostatectomy to combined radiation and hormonal therapy in high-risk patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据