期刊
CURRENT HIV/AIDS REPORTS
卷 9, 期 1, 页码 91-100出版社
SPRINGER
DOI: 10.1007/s11904-011-0104-6
关键词
Single copy assay; Residual viremia; HIV reservoirs; HIV quantification; Ultrasensitive PCR; HIV treatment intensification
资金
- National Institute of Allergy and Infectious Disease [T32 AI065380]
- Division of AIDS (University of Pittsburgh CTU) [1U01 AI069494- 01]
- Virology Support Laboratory subcontract [204VC009]
- ACTG Central Group Grant [1U01AI068636- 01]
- NCI [25XS119]
Quantification of plasma HIV-1 RNA below the limit of FDA-approved assays by a single copy quantitative PCR assays (SCA) has provided significant insights into HIV-1 persistence despite potent antiretroviral therapy as well as a means to assess the impact of therapeutic strategies, such as treatment intensification, on residual viremia. In this review, we discuss insights gained from plasma HIV-1 RNA SCA and highlight the need for additional assays to characterize better the cellular and tissue reservoirs of HIV-1. Accurate, reproducible, and sensitive assays to quantify HIV-1 reservoirs, before and after therapeutic interventions, are essential tools in the quest for a cure of HIV-1 infection.
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