Electrochemical- and Fluorescent-Mediated Signal Amplifications for Rapid Detection of Low-Abundance Circulating Tumor Cells on a Paper-Based Microfluidic Immunodevice

The design of a novel paper-based microfluidic immunodevice with combined electrochemical- and fluorescent-mediated signal amplifications for the highly specific and ultrasensitive point-of-care detection of rare circulating tumor cells is reported.