期刊
CATALYSTS
卷 8, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/catal8080321
关键词
rutin oligomers; laccase activity; aqueous solubility; antioxidant activity; xanthine oxidase inhibition; MALDI-TOF; HPSEC
资金
- Spanish Ministry of Economy and Competitiveness [CTQ2014-58879-JIN, IJCI-2015-25305]
- Galician Competitive Research Group [GRC-ED431C 2017/29]
- CRETUS [AGRUP2015/02]
- FEDER
The enzyme-mediated polymerization of bioactive phenolic compounds, such as the flavonoid rutin, has gained interest due to the enhanced physico-chemical and biological properties of the products, which increases their potential application as a nutraceutical. In this work, the influence of enzyme activity on rutin oligomerization was evaluated in reactions with low (1000 U/L) and high (10,000 U/L) initial laccase activities. For both reactions, high molecular weight oligomer fractions showed better properties compared to lower weight oligomers. Products of the reaction with low laccase activity exhibited thermal stability and antioxidant potential similar to control reaction, but led to higher inhibitory activity of xanthine oxidase and apparent aqueous solubility. Oligomers obtained in the reaction with high laccase activity showed better apparent aqueous solubility but decreased biological activities and stability. Their low antioxidant activity was correlated with a decreased phenolic content, which could be attributed to the formation of several bonds between rutin molecules.
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