期刊
BIOLOGY OF SEX DIFFERENCES
卷 3, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/2042-6410-3-11
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资金
- NCRR NIH HHS [UL1 RR024992] Funding Source: Medline
- NIDDK NIH HHS [P30 DK056341, P60 DK020579, R01 DK049393] Funding Source: Medline
Background: Although there appear to be no differences in muscle protein turnover in young and middle aged men and women, we have reported significant differences in the rate of muscle protein synthesis between older adult men and women. This suggests that aging may affect muscle protein turnover differently in men and women. Methods: We measured the skeletal muscle protein fractional synthesis rate (FSR) by using stable isotope-labeled tracer methods during basal postabsorptive conditions and during a hyperaminoacidemic-hyperinsulinemiceuglycemic clamp in eight young men (25-45 y), ten young women (25-45 y), ten old men (65-85 y) and ten old women (65-85 y). Results: The basal muscle protein FSR was not different in young and old men (0.040 +/- 0.004 and 0.043 +/- 0.005%.h(-1), respectively) and combined insulin, glucose and amino acid infusion significantly increased the muscle protein FSR both in young (to 0.063 +/- 0.006%.h(-1)) and old (to 0.051 +/- 0.008%.h(-1)) men but the increase (0.023 +/- 0.004 vs. 0.009 +/- 0.004%.h(-1), respectively) was similar to 60% less in the old men (P=0.03). In contrast, the basal muscle protein FSR was similar to 30% greater in old than young women (0.060 +/- 0.003 vs. 0.046 +/- 0.004%.h(-1), respectively; P<0.05) and combined insulin, glucose and amino acid infusion significantly increased the muscle protein FSR in young (P<0.01) but not in old women (P=0.10) so that the FSR was not different between young and old women during the clamp (0.074 +/- 0.006%.h(-1) vs. 0.072 +/- 0.006%.h(-1), respectively). Conclusions: There is sexual dimorphism in the age-related changes in muscle protein synthesis and thus the metabolic processes responsible for the age-related decline in muscle mass.
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