期刊
BIOLOGY OPEN
卷 1, 期 3, 页码 275-285出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/bio.2012380
关键词
Myocardial Progenitors; Apelin Receptor; Gastrulation; Zebrafish
类别
资金
- Restracomp
- Research Training Center at the Hospital for Sick Children
- Canadian Institutes for Health Research [86663]
Myocardial progenitor development involves the migration of cells to the anterior lateral plate mesoderm (ALPM) where they are exposed to the necessary signals for heart development to proceed. Whether the arrival of cells to this location is sufficient, or whether earlier signaling events are required, for progenitor development is poorly understood. Here we demonstrate that in the absence of Aplnr signaling, cells fail to migrate to the heart-forming region of the ALPM. Our work uncovers a previously uncharacterized cell-non-autonomous function for Aplnr signaling in cardiac development. Furthermore, we show that both the single known Aplnr ligand, Apelin, and the canonical G alpha(i/o) proteins that signal downstream of Aplnr are dispensable for Aplnr function in the context of myocardial progenitor development. This novel Aplnr signal can be substituted for by activation of Gata5/Smarcd3 in myocardial progenitors, suggesting a novel mechanism for Aplnr signaling in the establishment of a niche required for the proper migration/development of myocardial progenitor cells. (C) 2012. Published by The Company of Biologists Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据