期刊
AGING AND DISEASE
卷 9, 期 5, 页码 924-937出版社
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2017.1126
关键词
Ischemic stroke; mitochondrial quality control; mitophagy; mitochondrial transfer; neuroprotection
资金
- National Natural Science Foundation of China [81601013, 81671130]
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
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